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CJC-1295 DAC 2mg

Item 12659

DAC CJC 1295

DAC conjugated CJC 1295 (Receptor Grade) is an hGH secretogue that is unique by way of an additional lysine molecule that is added to facilitate the DAC complex. This conjugation makes for a much longer half-life.  DAC CJC 1295 tends to have a very limited availability everywhere due to expense and difficulty to manufacture.  CJC 1295 DAC is a exceptionally designed peptide and is known for being the finest of the hGH secretogues. Receptor grade: 98%+ pure 2000mcg / 2ml glass vial. THIS PRODUCT IS INTENDED FOR RESEARCH PURPOSES ONLY. CAN BE HARMFUL IF USED INAPPROPRIATELY.

In the healthy human body, large amounts of growth hormone are stored in the pituitary.  The cells within the pituitary release growth hormone in response to signalling by GHRH (Growth Hormone Releasing Hormone), Ghrelin (of which GHRPs - Growth Hormone Releasing Peptides - are mimetics), and are inhibited from releasing these stores by Somatostatin.  GHRH and Ghrelin act on different populations of somatotropes (GH releasing cells).  GHRP/Ghrelin increases the number of somatotropes releasing GH but not the amount released by each cell;
GHRH affects both the number of secreting cells and - moreso - the amount they each secrete. [1] GHRH and Ghrelin are released in specific patterns that vary depending on event and environment: post-exercise, in response to slow wave sleep, in certain stages of life and physical development, and so on.

Most people (even the diseased) continue to possess the ability to make GH in the pituitary. The problem is in the signalling of the pituitary to release it (and make more). So yes CJC is meant to replace the external administration of GH in some (but not all) cases.Even most people with diseases that affect growth hormone secretion retain the ability to continue to make GH in their pituitaries.  The disease states and symptoms result, most typically, in altered (dysfunctional) GH release signalling and this also affects the ability of the pituitary to continue to make more GH. [2]

GHRH, which has a forty-four amino acid long chain (and a specific shape - thus making it a peptide as well as a hormone), has been marketed for the longest as Sermorelin.  However, Sermorelin has been demonstrated to be degraded rapidly in the body and is cost-inefficient.  But because most patients in need of GH therapy doretain the ability to produce and secrete their own GH, treatment with a GHRH-type analog remained hypothetically preferable to exogenous  GH treatment.  GH itself when administered exogenously results not only in "unnatural" release patterns, it results universally in downregulation of endogenous GH production - as do many hormones when applied exogenously.  [2]

Sermorelin's limitations naturally resulted in a variety of formulations of GHRH analogs for therapeutic.  The most effective (in terms of minimal degradation in the body - which is different from half-life)  analogs with the longest half-lives were those created with an attached 3-maleimidopropionic acid (MPA) unit, which results in binding to albumin after exogenous injection into blood plasma.
The research chemicals CJC-1293 and CJC-1295 are GHRH (the 44-amino acid long version) with 15 aminos removed, thus a total of 29 amino acids, and bound to MPA. [2]  MPA is also called Drug Affinity Complex, and CJC-1295 is often referred to as GHRH with Drug Affinity Complex (DAC).

Based on measured GH release in rats over a two hour period, CJC-1295 released twice as much GH as CJC-1293, thus rendering it preferable based on immediate effectiveness; however, CJC-1293 has a 9% edge in stability (meaning less degradation) with in vitro stability tests.
CJC-1293, over a two-hour period, results in a rise-fall-rise-fall type pattern whereas CJC-1295 results in more of an inverted-U shape with a more gentle and longer peak. [2]

In a CJC-1295 pulsatility study performed on normal non-GH deficient people reported plasma levels were between 1 and 2 ng/ml or 1000-2000ng/L one week after injection of between 60 or 90 mcg/kg of CJC-1295. In a 100kg man that is a 6mg or 9mg per week dose.

"Knockout rats" are mice with genetically removed M3 muscarinic acetylcholine receptors. The scientists conducting the study [4] inhibited these genes and the mice became dwarves.. Those mice, labeled Br-M3-KO mice experienced short stature and a shrunken pituitary.  Scientists treated Br-M3-KO mice and normal control mice with CJC-1295 for eight weeks, resulting in complete growth restoration in the knockout mice as well as - notably - a restored pituitary size.  More specific data regarding CJC-1295 can be extrapolated by examining some of the control mice, which were not "knockout rats" but still received CJC-1295. The controls, male and female, experienced both accelerated & increased overall growth over the non-CJC-1295-dosed controls. Referring back to the notable finding that pituitary size was restored in knockout specimens dosed with CJC-1295, it is equally notable that the controls who did receive CJC-1295 did not have any pituitary hyperplasia or growth of the pituitary whatsoever.  This supports the conclusion that CJC-1295 is a substantially less risky treatment for non-diseased subjects, and a substantially more beneficial therapy for subjects with pituitary disease, than conventional (synthetic) GH treatment.  [4]

In conclusion, CJC-1295 is an exciting treatment from the standpoint of cost efficiency, safety, and ease of administration when compared with regular GHRH or synthetic Growth Hormone treatment.  It has been demonstrated to be as effective as GH for most uses, and vastly preferable for safety reasons where feasible.  GH will not be fully supplanted by GHRH analogs such as CJC-1295 for  reasons alluded to above, but the vast majority of treatments in the types of applications mentioned in this article will probably begin to use CJC-1295 for safety, cost-efficiency, and the need to administer only one or two times per week instead of multiple times per day. [3]

Citations:
[1] Lewis UJ. Growth hormone: what is it and what does it do? Trends Endocrinol Metab 1992;3:117-121
[2] Synthesis and Biological Evaluation of Superactive Agonists of Growth Hormone-Releasing Hormone, J Izdebski, J Pinski, JE Horvath, G Halmos, K Groot and AV Schally, Proceedings of the National Academy of Sciences, Vol 92, 4872-4876
[3] Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long- Acting GH-Releasing Hormone Analog, Madalina Ionescu and Lawrence A. Frohman, The Journal of Clinical Endocrinology & Metabolism 2006 91(12):4792-4797
[4] Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth, Dinesh Gautam, PNAS April 14, 2009 vol. 106 no. 15

Russianstar " EXPERIENCES WITH CJC-1295 DAC"

 

Written by Russianstar, This information is copyrited.

Firstly lets explain what the peptide CJC-1295 DAC is.

Molecular Formula: C152H252N44O42

Molecular Weight: 3368.7

Sequence of CJC1295 (modified) without DAC:

H-Tyr-(D)Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-

Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

CJC-1295 is a GHRH (the 44-amino acid long version) with 15 aminos removed, thus a total of 29 amino acids, and bound to DAC it is also called Drug Affinity Complex, and CJC-1295 is often referred to as GHRH with Drug Affinity Complex, this essentialy lengthens its life span.
This is how its life is lengthened.
The modification of growth hormone releasing factor with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 2 create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By utilising the Drug Affinity Complex technology to GRF, the peptide selectively binds to circulating albumin after subcutaneous administration, thus prolonging its half-life.
As you may notice its basicly semorelin with 15 aminos removed. This was because semorelin degrades too rapidly to really make it a viable cost efficient option.
So they bonded it with an attached 3-maleimidopropionic acid (MPA) unit, which results in binding to albumin after exogenous injection into blood plasma, and creates a far longer half life, this is the DAC, or druf affinity complex i made referance to earlier.
Now it works by this action as its a GHRH, or growth hormone releasing hormone, In the healthy human body, large amounts of growth hormone are stored in the pituitary. The cells within the pituitary release growth hormone in response to signalling by GHRH (Growth Hormone Releasing Hormone) Then the peptide Ghrelin is (of which GHRPs - Growth Hormone Releasing Peptides - are mimetics), inhibited from releasing these stores by Somatostatin. GHRH and Ghrelin act on different populations of somatotropes (GH releasing cells). GHRP and Ghrelin increase the number of somatotropes releasing GH but not the amount released by each cell.
GHRH affects both the number of secreting cells and - moreso - the amount they are actualy able to secrete. GHRH and Ghrelin are released in specific patterns that vary depending on what the person involved is doing, or has been doing post-exercise. Now CJC-1295 DAC has been proven to stimulate slow wave sleep, and this is the period of sleep when most of your bodys repairing work takes place on muscles and tissues etc.
Now most people can and will make GH in their own pituitary gland, but not everyone can release it in the amounts needed, so from a medicinal point CJC-1295 DAC can be very beneficial.

Now for its benefits to reach full potential, somatostatin needs to be inhibited because we have just seen it inhibits gh release, so by using a compound known as an Acetylcholineesterase inhibitor, now Acetylcholineesterase inhibits acetylcholine, and Acetylcholine inhibits somatostatin, so we want Acetylcholine in abundance, so by using an Acetylcholineesterase inhibitor, we allow acetylcholine to inhibit somatostatin, so increasing the amount of gh released when using CJC-1295DAC. Got it? Ok re read that last passage.
The best of these Acetylcholineesterase inhibitors and there are lots like..
Physostigmine
Neostigmine
Pyridostigmine
Ambenonium
Demarcarium
Rivastigmine
Phenanthrene derivatives
Galantamine
Piperidines
Donepezil, also known as E2020
Tacrine, also known as tetrahydroaminoacridine (THA')
Edrophonium
Huperzine A
Ladostigil,
Of the ones ive tried Huperzine A is the very best, and fairly cheap, now by adding ECGCs from green tea, as these ECGCs will transport the huperzine better so finding the receptor it needs the effects are even stronger on inhbiting the acetylcholineesterase.
Otherwise a really good one i used recently was Horny goat weed, its the only one i know that actualy increases acetylcholine as it inhibits the enzyme acetylcholinesterase.
Personally i rate this as my favourite peptide, you get nearly a constant surge in gh especialy if you add in say huperzine A, you get all the benefits of hgh, improved body composition, anabolic effects, injury recovery, improved skin, the full works, and at a very good price, far cheaper than real gh.
I have found that between 2000mcg -5000mcg a week has given me great results, increased bodymass over a 15 week period of nearly 9lbs, thats not weight gained, thats pure muscle and fat loss, You get all the same benefits of hgh, but you get them constantly, not just in one or 2 surges when you use the injections.
Now i would use this in fat deposits as i noticed a reduction when i did so quite quickly, and directly into a muscle with this is quite painfull to say the least, so thats a no no from me.
Expect to see results after just a couple of weeks, and the large amounts of igf-1 released will really add some muscle when incoorporated with a good diet and training regime.

There are no sides ive seen with cjc just positive ones except for the amazingly strong head rush you get about 20 mins after the injection, this a tell tale sign as to wether or not you have the real thing.
Remember the pulses are not as big as when you use GHRP-6, but rather its a continuous elevation of gh secretion peaking about 2 hours after the injection and staying elevated for 14 days. I use it 4 times a week in 500mcg doses and find this to be perfect for maintaining muscle when unable to train, say because of injury, and improving skin tone and health.
3500mcg is a far more anabolic dose and muscle mass will be noticeably improved after 4 weeks, and the skin will start to take on that shredded ultra thin look that gh users get before competitions.
All the benefits of real GH, less injections, less sides, a lot less money.... need i say more.

I hope you have found this information helpfull, i feel its one of the very best peptides if not the best.

Russianstars peptide rating 9/10

 



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