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GHRP – 2

Item 12651

Growth Hormone Releasing Peptide-2 (GHRP-2)

 

Growth Hormone Releasing Peptides or Peptides stimulating endogenous Growth Hormone secretion

Growth Hormone Releasing Peptides (GHRP-2, GHRP-6 and Hexarelin) are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH). These peptides were discovered 20 years ago and in clinical researches proved to be able to stimulate pituitary to produce endogenous Growth hormone.

GHRP-2, GHRP-6 and Hexarelin are replaceable drugs and have similar mechanism of action.

Hexarelin is considered to be the strongest peptide stimulating GH secretion. With its use, the increase in cortisol and prolactin levels is also high enough. GHRP-2 is less strong than Hexarelin, but the increase in cortisol and prolactin levels is less too. GHRP-6 is less strong than GHRP-2, but when used in dosage up to 100mcg, it has no influence on the levels of cortisol and prolactin, and in dosage more than 100mcg, the increase in cortisol and prolactin levels is modest.

Another drug stimulating endogenous GH secretion is long-acting CJC-1295 (Long-acting Growth Hormone Releasing Hormone Analog).

Common dosage regimen of Peptides:

Cycle: 16 months. The dosage is prescribed individually and injected 1-6 times a day starting with 25-50mcg and gradually increasing it with the step of 25-50mcg to achieve minimal side effects. Then, there should be return to the starting dose. The injections are usually made subcutaneously in an abdominal area 30 minutes before or in 1-1.5 after meal. The time between injections should be 3-4 hours (in order the body has the time to produce GH for further release).

Growth Hormone Releasing Peptide-2 (GHRP-2)

Growth Hormone Releasing Peptide-2 (GHRP-2) is a peptide made up of just six amino acids, which stimulates secretion of endogenous GH. In researches, GHRP-2 showed ability to stimulate the pituitary to increase secretion of GH by 7-15 times, to stimulate ghrelin receptors and in such a way to promote appetite.

According to the results of clinical trial, which were published in The Endocrinology and Metabolism Magazine in 1997, GHRP-2 increases GH secretion both in adults and children, and even in elders.

The main effects of GHRP-2 are GH secretion stimulation, appetite promotion, fat mass decrease and muscle mass increase, lowering of cholesterol level, skin and bones state improving, defense of the liver and anti-inflammatory action.

The researches confirmed high safety of GHRP-2 and almost no side effects, if GHRP-2 is administered within the recommended dose range. GHRP-2 has been clinically trialed for 30 years. Thus, delayed side effects can be excluded.

 


GHRP2 adult therapy benefits

 

  • Improve sex drive and desire by stimulation of hypothalamus
  • Reduces belly fat through lipolysis
  • Increases energy and vitality
  • Improves skin elasticity, ridding wrinkles
  • Increases endurance
  • Accelerates healing from wounds or surgery
  • Strengthens the heart
  • Enhances the immune system
  • Increases IGF-1 production, by as much as
    50% in first week
  • Improves sleep quality
  • Increases calcium retention, strengthens and increases the mineralization of bone, bone density
  • Increases protein synthesis,
  • Improves eyesight and vision
  • Reduces liver uptake of glucose, an effect that opposes that of insulin
  • Promotes liver glucogenesis
  • Contributes to maintenance and function of pancreatic islets

GHRP2 growth hormone releasing peptide2 therapy is considered one of a few medical means of reversing the effects of aging in adults deficient in growth hormone. This is because of the benefits resulting from the increased stimulation and secretion of human growth hormone by the pituitary gland hypothalamus,axis HPA.




Growth Hormone Releasing Peptide - 2 (GHRP2)

Is a synthetic six amino acid peptide that has robustly potent properties.

GHRPs are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH) through the activation of a specific, G protein-coupled receptor.


They were discovered 20 years ago as synthetic metenkephalin- derived oligopeptides (Synthetic tissue derived amino acids). Although it has no structural homology with Growth Hormone Releasing Hormone (GHRH), in clinical studies GHRP-2 demonstrated action on the pituitary to release Human Growth Hormone (HGH). Similar results were effective when GHRP-2 was administered sublingual. Clinical studies showed the most potent GHRP being the hexapeptide GHRP-2.


Growth Hormone Releasing Peptide 2(GHRP2) substantially stimulates the pituitary gland's increased natural production of the body's own endogenous human growth hormone (HGH). This therapy consists of daily periodic sub-lingual dosing. Growth Hormone releasing peptide 2, GHRP2 has shown on it's own to robustly increase IGF-1 levels, and even greater results occurred when used with Growth Hormone Releasing Hormone (GHRH) to which also stimulates the pituitary gland to produce increased natural secretion of human growth hormone. This also boosts the hypothalamus function as well.


The results of the clinical studies published in the Journal of Endocrinology and Metabolism in 1997 for GHRP2 - showed that a medically supervised, prescribed and administered therapy increased growth hormone levels in adults and children, who have growth hormone deficiency.


The increase in the body's growth hormone via elevated IGF-1 levels produced by the pituitary gland in response to GHRP2 therapy -- has an anabolic effect on the tissues of the body and other benefits identified below.


Frequently asked Questions

Q: Why use GHRP2 instead of Growth Hormone?

A: This can be used alone or as an adjunct to HGH therapy. Both methods will yield robust results. The synergy of using GHRP2 with injectable growth hormone is that it allows your own natural production to remain and rebuild along with the use of injectable growth hormone. GHRP2 works greatly on it's own as well.


Q: I have heard of using growth hormone orally and don't have much faith in this manner of its application. Can you explain about this?

A: Growth hormone has a brief half life and is rendered ineffective when orally applied, swallowed and passed into the gastric tract. Then it must pass through the liver when applied orally. This is why HGH is effectively administered through subcutaneous injections. Conversely, GHRP2 oral mucosal medicine delivery i.e.: sublingual/ intranasal as demonstrated in clinical studies, is an effective alternative method of systemic medicine /supplement delivery that offers not only impressive results -- but several advantages over both injectable and enteral methods.

 

Because the oral mucosa is highly vascularised, medi-suppliments that are absorbed through the oral mucosa directly enter the systemic circulation, bypassing the gastrointestinal tract and first pass metabolism in the liver. For some supplements and drugs, this results in rapid onset of action via a more comfortable and convenient delivery route than the intravenous route. Not all medications, however, can be administered through the oral mucosa because of the characteristics of the oral mucosa and the physicochemical properties of the supplement.

 

GHRP2 can be delivered sublingual and is the preferred method of application -- and in a peer reviewed clinical study from the Department of Pediatrics at the University of Arkansas for Medical Sciences, published in the Journal of Endocrinology and Metabolism in 1995, "All 15 children had a significant GH response to 15 pg/kg dose. The intranasal /mucosa delivery was well tolerated."



GHRP-2 growth hormone releasing-hormone

 

GHRP-2 is a synthetic ghrelin analogue. Like ghrelin, it stimulates release of endogenous growth hormone from somatotropes in the anterior pituitary; also like ghrelin, it is synergistic with endogenous growth hormone releasing-hormone (GHRH) as well as with synthetic GHRH analogues such as Sermorelin or GRF(1-29). [3] Whereas GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means.[1] Unlike ghrelin, GHRP-2 is not lipogenic meaning it does not induce fat storage. While ghrelin has a very important role in hunger, GHRP-2 as an analog of ghrelin does not increase appetite significantly.[1]

GHRP-2 is synergistic with GHRH due to secondary actions on hypothalamic neurons. [2] The quantity of GH released by a living mammal to which GHRP-2 and GHRH are administered exceeds the combined release of each compound when measured when taken alone. [2]

The neuronal excitation in the hypothalamus lasts for an hour or so with GHRP-2 dosing, quickly causing a high-amplitude pulsation of GH which tapers back to baseline by the third hour after application.[4] This pulse closely resembles natural or endogenous GH release, and for many purposes is likely superior in application to the synthetic GH circulation period of eight hours. Cellular desensitization to the effects of GH is more likely to occur with a longer, shallower pulse.[5]

Age-related GH decline, as well as other potential issues that might be treated with GHRP-2, is not a result of inability to produce GH but rather is due to a reduction in signaling. The aged pituitary of humans can still produce the same amount of GH with the same frequency, but the signaling compounds ghrelin and endogenous GHRH are released in different patterns creating a loss in GH production relative to youthful states or healthful states.[5]

In humans, a dose of 1mcg/kg (100mg for a 100kg male) of GHRP-2 when combined with a GHRH of equal dosage creates a three-hour pulse of GH that is double the amplitude of an 8 IU synthetic (e.coli derived) growth hormone dose.[4] IV, intramuscular and subcutaneous routes lead to different onset times but roughly similar peaks and declines. Due to ease of synthesis (as opposed to the complicated process of creating GH from e. coli), safety, and lower cost, GHRP-2 as part of comprehensive therapy may soon supplant conventional exogenous GH therapy.

References:

[1] Bercu, B.B., Yang, S-W., Masuda, R. and Walker, R.F. (1992) Role of selected endogenous peptides in growth hormone releasing hexapeptide (GHRP) activity: analysis of GHRH, TRH and GnRH. Endocrinology 130, 2579–2586.
[2] Chen, C., Wu, D. and Clarke, I.J. (1996) Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs. J. Endocrinol. 148, 381–386
[3] Frohman, L.A., Downs, T.R. and Chomczynski, P. (1992) Regulation of growth hormone secretion. Front. Neuroendocrinol. 13, 344–40

[4] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205
[5]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464.

GRF - GHRP - GH a comprehensive dosing protocol

 

In effort to list a protocol for the use of GHRP / GRF / and in combo with GH if desired I thought I would post my current protocol based upon the research I have done within the last year or so. Obviously the information I gathered is not based on medical studies completed by me but I do use the following protocol myself and have been pretty damed impressed with the results. Recovery from injury is very impressive to me (any kind of injury). Example, 5 days ago I was lifted by the butt of a tree I cut down (long story). I had bruising and some serious raspberry on my under arm, left quad and my abs ( the but of the tree ran right up the front of my once it got under my arm it lifted me and tossed me about 10 feet through the air). Its been 5 days and all that is left of the raspberries are some faint red marks......amazing IMO.

Also: I encourage others to do their own research. Don't think all that I have written below is gospel or the only / best way to run these peptides. This is nothing more than my interpretation of what I have read and what I perceive as the best way to use peptides.

Best Choices for GHRP's.

GHRP-6 Good GH spike when used with a GRF, large increase in hunger. Elevates prolactin and cortisol levels
GHRP-2 Good GH spike, when used with a GRF, on par with GHRP-6 without the hunger. Elevates prolactin and cortisol levels
Ipamorelin good GH spike when used with a GRF. GH spike is not as high as GHRP-2 or 6 but it does not elevate prolactin or cortisol.

Note: in order for a GHRP to have a positive affect and create a GH spike alone one as to be very lucky in the timing and hope it is injected at time when Somatostatin is low in the body. Somatostatin blunts GH release in the presence of just GHRP. Using GRF will override the signal presented by Somatostatin so you will get a very dramatic GH pulse.

GRF's (GHRH)
Two choices

Mod GRF 1-29, higher GH peaks, short half life (30 minutes) most closely mimics your bodies own GH pulses but far greater amplitude
CJC 1295 long half life (7days). Lower GH amplitude when used with GHRP, raises the troughs in the bodies GH level profile, the downside is it creates GH bleed. Think of the GH as being stored in a jar until someone (thing) opens up the faucet. It is best if the jar is full and then dumps. CJC does not allow the jar to fill. Current recommendations are to avoid CJC

Saturation dose for any of the GHRH's or GHRP's including Ipamorelin is 100mcg (or 1mcg / kg of bodyweight) so this is all based on a 100mcg dose.

As you may know, it is best to pin 1.5 to 2 hours after eating any fats or carbs and then after you pin don't eat any fats or carbs for 20-30 minutes as they will blunt the GH release. Pure protein is OK but I try to avoid all foods. Also, pure protein is OK anytime prior to pinning.

Dosings should be 3 hours apart or more.

Mornings upon waking pre cardio (if you are doing any), afternoon (or PWO) and before bed pin mod GRF 1-29 / GHRP (or Ipamorelin) @ 100mcg / 100mcg. (2 pinnings per day are also adaquate for improvements in recovery, better sleep etc. 3 will make you a bit more anabolic than 2 and you can even go 4 if the pocket book allows.

If you include GH in this protocol it should be 10 minutes after the peptides. So, first pin the peptides, wait 10-15 minutes and then pin your GH. Reason being is that Exogenous GH administration can also blunt GH release.

Wait 20-30 minutes after pinning the peptides and you are free to eat.

When you recon your peptides use as little BW as you can. I don't go as low as some people because I figure I don't want to leave a drop of highly concentrated peptide in the vial that I can not get out. The less BW used for recon the less the degradation of the peptide over time.

If you premix a shot ahead of time, don't let it sit mixed for more than 8 hours or so. When mixed they will exchange ions and who know what the final compound would be called :-). I actually have a way to preload without mixing the peptides until I am ready to pin it.

Do not pin IGF within 1 hour of pinning your peptides. IGF has a feedback loop that inhibits GH release.

With the above for pinning around workouts to get the most of your investment....

Pin insulin (humalin R) immediately PWO
wait 10 minutes pin peptides
If using GH wait 10 more minutes and pin the GH (see above for reasoning)
If using IGF wait approx. 1 hour PWO and pin the IGF.

IGF blunts GH release. another reason to wait is in effort to keep the IGF local you want to wait until you lose your pump. Blood flow is reduced in teh area of injection. if you pin IGF immediately PWO blood flow is still very high so the IGF get transported away too quickly..

For convenience...
Pin insulin Pre work out.... Humalin R is active for 4-5 hours
PWO pin peptides (or if you want to pin slin and peps at the same time PWO)
10 minutes after peps pin GH if you are using GH
30-60 minutes PWO pin IGF if using IGF

by: Bilter




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